Article

Vaccine Efficacy of a Replication-Competent Interferon-Expressing Porcine Reproductive and Respiratory Syndrome (PRRS) Virus against NADC-34 Challenge

2025-03-05

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) poses significant challenges to swine production due to its rapid generation of genetic variants and its ability to suppress antiviral interferon (IFN) responses, leading to ineffective immunity. To address this, we developed a replication-competent PRRSV modified live vaccine (MLV) candidate, IFNmix, engineered to co-express three type I IFN subclasses (...

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Literature Corpus work: f50182f5-27da-5ecf-bd0a-f1c62c5a8c4e
DOI: 10.20944/preprints202503.0288.v1

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