Back to search

Article

Downregulation of cancer hallmarks and immune check-points in patients with glioblastoma following a short course of the pro-oxidant combination of Resveratrol and Copper

2025-02-24

Abstract excerpt

<h4>Background</h4> We investigated a novel therapeutic approach to glioblastoma (GBM) that targets cell-free chromatin particles (cfChPs) that are released from dying GBM cells and aggravate the oncogenic phenotype of living GBM cells. cfChPs can be deactivated by oxygen radicals (OR) generated upon admixing the nutraceuticals Resveratrol (R) and Copper (Cu). Oral administration of R-Cu leads to generation of OR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f471cb6f-2909-5c21-90bc-0e1b4ea8418a
DOI
10.1101/2025.02.19.25322384
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Downregulation of cancer hallmarks and immune check-points in patients with glioblastoma following a short course of the pro-oxidant combination of Resveratrol and CopperDOI 10.1101/2025.02.19.25322384
A pro-oxidant combination of resveratrol and copper down-regulates hallmarks of cancer and immune checkpoints in patients with advanced oral cancer: Results of an exploratory study (RESCU 004)Semantic proximity
Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trialSemantic proximity
Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiationSemantic proximity
The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent EffectsSemantic proximity
Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen speciesSemantic proximity
Enhancing Therapeutic Approaches in Glioblastoma with Prooxidant Treatments and Synergistic Combinations: <em>In Vitro</em> Experience of Doxorubicin and Photodynamic TherapySemantic proximity
Exploring the role of Disulfidptosis in glioma progression: insights into tumor heterogeneity and therapeutic potential through single-cell RNA sequencingSemantic proximity
Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer TherapeuticsSemantic proximity
Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma.Semantic proximity
Deciphering the Dose-Dependent Effects of Thymoquinone on Transcriptomic Changes and Cellular Proliferation in GlioblastomaSemantic proximity
Curcumin-Induced Molecular Mechanisms in U-87 MG Glioblastoma Cells: Insights from Global Gene Expression ProfilingSemantic proximity
Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory ActivitiesSemantic proximity
Select a neighboring publication to make it the new centre.