Super-enhancer-associated LINC00963 promotes epithelial-mesenchymal transition in gastric cancer

Abstract excerpt

<h4>Background: </h4> In clinical practice, gastric cancer (GC) is a common malignancy with high morbidity. Accumulating research has revealed that lncRNAs are involved in the development and metastasis of tumor tissues in multiple cancers. As reported, LINC00963, a typical lncRNA is aberrantly expressed in gastric cancer. However, the underlying mechanisms of super-enhancers mediating remain unclear. Materials an...

Topics

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• Adaptor Proteins, Signal Transducing
• Cancer-related molecular mechanisms research
• Gene Knockdown Techniques
• Hippo Signaling Pathway
• Mice, Inbred BALB C
• Mice, Nude
• RNA, Long Noncoding
• Stomach Neoplasms

Identifiers and source

Literature Corpus work

f0660925-fea5-5862-8ce6-df944936eb93

DOI

10.21203/rs.3.rs-4020742/v1