Article

Segment-specific promoter activity for RNA synthesis in the genome of Oz virus, genus <i>Thogotovirus</i>

2024-10-31

Abstract excerpt

Oz virus (OZV), a tick-borne, six-segmented negative-strand RNA virus in the genus Thogotovirus, caused a fatal human infection in Japan in 2023. To investigate mechanisms of viral RNA synthesis, we developed an OZV minigenome assay used in mammalian cells. Comparisons of promoter activities across six segments revealed that Segment 5 exhibited markedly lower promoter activity. Unlike the other segments forming a...

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Literature Corpus work: eb70cd55-ed5d-564e-842c-4cc7f2692146
DOI: 10.1101/2024.10.31.621000

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