Integrative in-silico analysis on phytocompounds of Pajanelia longifolia against hepatocellular carcinoma: gene network target identification, molecular docking, simulation and ADMET profiling

Abstract excerpt

<title>Abstract</title> <p> Hepatocellular carcinoma (HCC) is one of the most common types of liver cancer, with a high mortality rate. Despite significant advances in HCC detection and treatment, problem remain persistence. Plant-derived natural products have always been a boon for novel medication development; in this case, <italic>Pajanelia longifolia</italic> is a traditional medicinal plant recognised for...

Topics

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• Berberine and alkaloids research
• Bioinformatics and Genomic Networks
• Computational Drug Discovery Methods
• Ferroptosis and cancer prognosis
• RNA modifications and cancer
• Single-cell and spatial transcriptomics
• Synthesis and biological activity

Identifiers and source

Literature Corpus work

e8809f94-0008-510f-baf4-0221ca881c02

DOI

10.21203/rs.3.rs-7782064/v1