Article

Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition

2019-12-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND AND AIMS</h4> Methotrexate is an important tool in the arsenal of oncologists, gastroenterologists, and rheumatologists. At low doses it induces intestinal barrier dysfunction that may induce side effects such as gastrointestinal discomfort and liver injury. Previous studies suggest that lactoferrin can improve barrier function in a variety of contexts. This study set out to dete...

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Literature Corpus work: e63da53f-9524-52f7-aae3-3db481d18f3d
DOI: 10.1101/2019.12.23.878207

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