Article

Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a synthetic gut community

2018-04-11

Abstract excerpt

Whereas the composition of the human gut microbiome is relatively well resolved, predictive understanding of its response to perturbations such as diet shifts is still lacking. Here, we followed a bottom-up strategy to explore human gut community dynamics. We established a synthetic community composed of three representative human gut isolates in well-controlled conditions in vitro. We then explored species inter...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e48e02a3-536e-55d7-a714-3a44c2980927
DOI: 10.1101/299644

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a synthetic gut communityDOI 10.1101/299644Read

Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut communitySemantic proximity Read

Deciphering microbial interactions in synthetic human gut microbiome communitiesSemantic proximity Read

Drivers of human gut microbial community assembly: Coadaptation, determinism and stochasticitySemantic proximity Read

Deciphering microbial interactions in synthetic human gut microbiome communitiesSemantic proximity Read

High-throughput cultivation of stable, diverse, fecal-derived microbial communities to model the intestinal microbiotaSemantic proximity Read

Ecological Engineering of the Human Gut Microbiome: A Review and Testable Framework for Next-Generation TherapeuticsSemantic proximity Read

Interspecies interaction controls <i>Escherichia coli</i> growth in human gut microbiome samplesSemantic proximity Read

Designs and methodologies to recreate in vitro human gut microbiota modelsSemantic proximity Read

Dynamic metabolic interactions and trophic roles of human gut microbes identified using a minimal microbiome exhibiting ecological propertiesSemantic proximity Read

Metabolic mechanisms of interaction within a defined gut microbiotaSemantic proximity Read

Optimization and standardization of the culturomics technique for human microbiome explorationSemantic proximity Read

Investigating a holobiont: Microbiota perturbations and transkingdom networksSemantic proximity Read