Article

Depletion of GPSM1 enhances ovarian granulosa cell apoptosis via cAMP-PKA-CREB pathway in vitro

2020-09-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Genetic causes of premature ovarian insufficiency (POI) account for approximately 20~25% of patients. So far, only a few genes have been identified. <bold>Results </bold>Here, we first identified the c.1840C>A on G-protein signaling modulator 1 (<italic>GPSM1</italic>) as a susceptibility locus for POI in 10 sporadic POI patients by whole-exome sequencing. The fr...

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Literature Corpus work: e3d50367-7a31-5aa3-817a-43ae7f1841a0
DOI: 10.21203/rs.3.rs-18442/v2

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