Article

Proteomics profiling of serum and liver in GSD Ia and Ib patients: insights into complication mechanisms and circulation biomarkers

2025-09-12

Abstract excerpt

<h4>Background</h4> Glycogen Storage Disease (GSD) Types Ia and Ib are rare metabolic diseases caused by gene variants in G6PC1 and SLC37A4, respectively. Although life-threatening fasting hypoglycemia can be controlled by a strict diet, patients often suffer from multiple metabolic abnormalities and severe long-term complications. However, the underlying mechanisms remain incompletely understood, and the lack...

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Literature Corpus work: e3d20422-0ee6-5370-b53f-cd53b126da2c
DOI: 10.1101/2025.09.08.674441

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