Cross-cohort analysis reveals conserved gut virome signatures and phage-encoded auxiliary functions in ulcerative colitis

Abstract excerpt

While gut bacteriome dysbiosis is a well-established hallmark of ulcerative colitis (UC), the ecological and functional remodeling of the gut virome conserved across diverse populations remains unclear. Here, by constructing a cross-cohort atlas of the UC-associated fecal virome, we show that viral reorganization closely parallels bacterial dysbiosis, with enrichment of phages targeting disease-associated bacteria...

Topics

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• Bacteriophages and microbial interactions
• Celiac Disease Research and Management
• Clostridium difficile and Clostridium perfringens research
• Cytomegalovirus and herpesvirus research
• Diet and metabolism studies
• Gut microbiota and health
• Respiratory viral infections research
• Viral gastroenteritis research and epidemiology

Identifiers and source

Literature Corpus work

e3aac0a9-ab8a-58de-9734-7e3326edbab9

DOI

10.64898/2026.01.21.700755