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Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models

2025-01-06

Abstract excerpt

<h4>Background: </h4> The majority of antigen-based SARS-CoV-2 (SCV2) vaccines utilized in the clinic have had the Spike protein or domains thereof as the immunogen. While the Spike protein is highly immunogenic, it is also subject to genetic drift over time that has led to a series of variants of concern that continue to evolve, requiring yearly updates to the vaccine formulations. In this study, we investigate t...

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Literature Corpus work
e0b7580d-0ca1-5a20-9900-8e7fd928bed9
DOI
10.20944/preprints202501.0305.v1
Open publication

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