Article

The Omicron Sub-Variant BA.4 Displays a Remarkable Lack of Clinical Signs in a Golden Syrian Hamster Model of SARS-CoV-2 Infection

2023-04-21

Abstract excerpt

The ongoing emergence of SARS-CoV-2 virus variants remains a source of concern because it is accompanied by the potential for increased virulence as well as evasion of immunity. Here we show that, although having an almost identical spike gene sequence as another Omicron variant (BA.5.2.1), a BA.4 isolate lacked all the typical disease characteristics of other isolates seen in the Golden Syrian hamster model despi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0161e89-9622-55d9-b04c-22ff1e468e69
DOI: 10.20944/preprints202304.0665.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Omicron Sub-Variant BA.4 Displays a Remarkable Lack of Clinical Signs in a Golden Syrian Hamster Model of SARS-CoV-2 InfectionDOI 10.20944/preprints202304.0665.v1Read

Comparing the Infectivity of Recent SARS-CoV-2 Omicron Sub-Variants in Syrian Hamsters.Semantic proximity Read

Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamstersSemantic proximity Read

Pathogenicity of SARS-CoV-2 Omicron BA.5 and BE.1 Variants in Syrian Hamsters and hACE2-transgenic MmiceSemantic proximity Read

Comparative analysis of SARS‐CoV‐2 Omicron BA.2.12.1 and BA.5.2 variantsSemantic proximity Read

Pathogenicity of SARS-CoV-2 Omicron in Syrian hamsters and its neutralization with different Variants of ConcernSemantic proximity Read

Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spikeSemantic proximity Read

The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineageSemantic proximity Read

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5Semantic proximity Read

The SARS-CoV-2 Omicron sub-variant BA.2.86 is attenuated in hamstersSemantic proximity Read

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48Semantic proximity Read

Characterization of SARS-CoV-2 Omicron BA.4 and BA.5 clinical isolatesSemantic proximity Read

Syrian hamster convalescence from prototype SARS-CoV-2 confers measurable protection against the attenuated disease caused by the Omicron variantSemantic proximity Read