Article

Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation

2021-05-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific immune mechanisms in SMI are not known yet. Recently, dyslipidemia has been linked to systemic inflammasome activation, and elevate...

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Literature Corpus work: dd82c317-ae63-5668-8d67-2b6448f0cd4a
DOI: 10.1101/2021.05.28.21258013

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