Article

Discovery of a Miniaturized PROTAC with Potent Activity and High Selectivity

2022-11-01

Abstract excerpt

<h4>Background: </h4> and Purpose The approved small-molecule inhibitors of anaplastic lymphoma kinase (ALK) have shown remarkable efficacy in some subset of cancer patients. However, the numerous ALK mutants or fusion partners are resistant to such drugs, greatly limiting their application in clinic. Despite the drug design strategy of proteolysis-targeting chimera (PROTAC) holds great potential to overcome drug...

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Literature Corpus work: dc945a16-b5ad-5606-b79c-ea040244ed3f
DOI: 10.22541/au.166728812.21148328/v1

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