Regulation of apolipoprotein a-1 and apolipoprotein b100 genes by thymoquinone rich fraction and thymoquinone in hepg2 cells

Abstract excerpt

Thymoquinone (TQ) rich fraction (TQRF) extracted from Nigella sativa seeds using a supercritical fluid extraction technique was prepared. The regulatory effects of TQRF at 80 μg/mL and commercial TQ at 2 μg/mL on apolipoprotein B100 (Apo B100) and apolipoprotein A-1 (Apo A-1) genes in the presence or absence of 25-hydroxycholesterol (25OH), were investigated in human HepG2 cell line using quantitative real-time po...

Topics

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• Biochemical Analysis and Sensing Techniques
• Cancer, Lipids, and Metabolism
• Cancer-related molecular mechanisms research
• Cholesterol and Lipid Metabolism
• Clusterin in disease pathology
• Diet, Metabolism, and Disease
• Ferroptosis and cancer prognosis
• Lipid metabolism and disorders

Identifiers and source

Literature Corpus work

dbb65a0f-82ce-532a-8f39-7cd13e8fdcc1

DOI

10.1111/j.1745-4522.2009.01144.x