Article

Deep learning models predicting hormone receptor status in breast cancer trained on females do not generalize to males: further evidence of sex-based disparity in breast cancer

2023-06-09

Abstract excerpt

<title>Abstract</title> <p>Breast cancer prognosis and management for both men and women are reliant upon estrogen receptor alpha (ERα) and progesterone receptor (PR) expression to inform therapy. Previous studies have shown that there are sex-specific binding characteristics of ERα and PR in breast cancer and, counterintuitively, ERα expression is more common in male than female breast cancer. We hypothesized th...

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Literature Corpus work: dbad4ea1-e88d-541c-ac18-e9a3ef2a1e0b
DOI: 10.21203/rs.3.rs-2996566/v1

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