Bing-Neel Syndrome in Waldenström Macroglobulinemia: Updates on Clinical Management and BTK Inhibitor Efficacy

Abstract excerpt

Bing-Neel syndrome (BNS) is a rare complication of Waldenström macroglobulinemia (WM) caused by the direct infiltration of the central nervous system (CNS) by lymphoplasmacytic cells. Since clinical manifestations are heterogeneous and overlap with IgM-related neuropathies, BNS is often under-recognized and diagnosed late. Due to its extreme rarity, there are no prospective studies on BNS. In 2025, a consensus pan...

Topics

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• Brain Diseases
• Combined Modality Therapy
• Diagnosis, Differential
• Diagnostic Tests, Routine
• Mutation
• Myeloid Differentiation Factor 88
• Syndrome
• Waldenstrom Macroglobulinemia

Identifiers and source

Literature Corpus work

daef3c68-276e-544e-b54b-e8fef6fe6a04

DOI

10.20944/preprints202509.1980.v1