Article

Prospective Study of Epigenetic Alterations Responsible for Isolated Hemihyperplasia/Hemihypoplasia and Their Association With Leg Length Discrepancy

2021-05-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Hemihyperplasia and hemihypoplasia result in leg length discrepancy (LLD) by causing skeletal asymmetry. Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS) are opposite growth-affecting disorders caused by opposite epigenetic alterations at the same chromosomal locus, 11p15, to induce hemihyperplasia and hemihypoplasia, respectively. Because of...

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Literature Corpus work: d93eaf0b-fb18-50b7-988f-1fcb90c97989
DOI: 10.21203/rs.3.rs-518137/v1

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