Article

Polybacterial intracellular coinfection of epithelial stem cells in periodontitis

2023-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Periodontitis affects billions of people worldwide. To address interkingdom relationships of microbes and niche on periodontitis, we generated the first sin-gle-cell meta-atlas of human periodontium (34-sample, 105918-cell), harmo-nizing 32 annotations across 4 studies 1–4 . Highly multiplexed immunofluores-cence (32-antibody; 113910-cell) revealed spatial innate and adaptive immune foci segreg...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d83c00e6-0ac7-582f-acae-7b0e304f012f
DOI: 10.1101/2023.08.23.554343

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polybacterial intracellular coinfection of epithelial stem cells in periodontitisDOI 10.1101/2023.08.23.554343Read

Deciphering Periodontitis: Host Mechanisms, Predictive Biomarkers, and Systemic Drivers for Precision PreventionSemantic proximity Read

Microbial signatures in human periodontal disease: a metatranscriptome meta-analysisSemantic proximity Read

Single-cell atlas of human oral mucosa reveals a stromal-neutrophil axis regulating tissue immunity in health and inflammatory diseaseSemantic proximity Read

Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity.Semantic proximity Read

CD38⁺ Endothelial Remodeling Defines Spatially Diverse Vasculopathy Programs in Rapidly Advancing Oral InflammationSemantic proximity Read

The Immunoregulatory Architecture of the Adult Oral CavitySemantic proximity Read

Single-cell RNA sequencing identifies heterogeneous cell subtypes within gingival tissueSemantic proximity Read

Differential Virulence of Aggregatibacter actinomycetemcomitans Serotypes Explained by Exoproteome HeterogeneitySemantic proximity Read

Subgingival Microbiota and Cytokines Profile Changes in Patients with Periodontitis: A Pilot Study Comparing Healthy and Diseased Sites in the Same Oral CavitiesSemantic proximity Read

Biogeographical Impacts of Dental, Oral, and Craniofacial Microbial ReservoirsSemantic proximity Read

Dual RNA sequencing of group B Streptococcus-infected human monocytes reveals new insights into host–pathogen interactions and bacterial evasion of phagocytosisSemantic proximity Read

Single-cell RNA-seq combined with bulk RNA-seq analysis identifies necroptosis-related genes as therapeutic targets for periodontitisSemantic proximity Read