Article

Internal and External Validation of Comprehensive High-Frequency Activity Biomarkers for Epilepsy Surgery

2025-12-19

Abstract excerpt

Although epilepsy surgery studies have proposed intracranial EEG–derived biomarkers for localizing seizure onset and anticipating postoperative outcomes, evaluation has often been limited to derivation cohorts using internal cross-validation. An influential notion holds that neurons distributed within the seizure onset zone (SOZ) frequently generate high-frequency activity (HFA) and that resection of such sites is...

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Literature Corpus work: d6ddbf0e-9ed1-535f-be1d-556f4f1f4f1d
DOI: 10.64898/2025.12.17.25342490

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