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Stem cell-derived small extracellular vesicles containing miR-27b-3p attenuated osteoarthritis by targeting leukaemia inhibitory factor expression of synoviocytes

2022-07-01

Abstract excerpt

Mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been demonstrated to be effective in the treatment of OA, but the precise target cells and response mechanisms are not well characterised. In this study, first, we found that intra-articular injection of human umbilical cord MSC (UCMSC)-derived sEVs (U-sEVs) significantly alleviated mouse OA. Then, U-sEVs were taken up rapidly and prefere...

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Literature Corpus work
d3199a5c-7856-51e3-b94f-69db7a425a87
DOI
10.21203/rs.3.rs-1759506/v1
Open publication

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