Article

Extraction of Human Phenotype Ontology (HPO) Concepts from Clinical Notes Utilizing Large Language Models (LLM) with Model Context Protocol (MCP)

2026-05-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Accurate extraction of Human Phenotype Ontology (HPO) terms from clinical notes is essential for variant prioritization and genetic diagnosis. Large language models (LLMs) often struggle to balance precision, hallucination avoidance, and ontology mapping accuracy, and prior work has shown that retrieval-based grounding can improve performance for individual models. We hypoth...

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Literature Corpus work: d1dc8df4-7fe1-58f0-b048-2ff3329c141e
DOI: 10.64898/2026.05.23.26353963

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