The Co-Regulation of the Gut Microbiome and Host Genes Might Play Important Roles in Metformin Intolerance

Abstract excerpt

<title>Abstract</title> <p>Background Metformin is commonly considered the first-line therapy for type 2 diabetes (T2D) and also had potential treating utility in other areas; however, ~20% of patients experience intolerance with unclear underlying mechanisms. In the present study, we performed the full-length 16S rRNA (V1-V9) for the fecal samples and bioinformatics analysis to study the mechanisms of the metfo...

Topics

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• Clostridium difficile and Clostridium perfringens research
• Diet and metabolism studies
• Dietary Effects on Health
• Gastrointestinal motility and disorders
• Gut microbiota and health
• Nutritional Studies and Diet
• Probiotics and Fermented Foods
• Tuberculosis Research and Epidemiology

Identifiers and source

Literature Corpus work

d0eb2d25-d14d-5ceb-af35-36559ff16b36

DOI

10.21203/rs.3.rs-965098/v1