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Ferroptosis-related genes coordinated with PD-L2 shapes matrix stiffness-driven tumor environment and predict hepatocellular carcinoma development

2022-02-28

Abstract excerpt

<h4>Background: </h4> Ferroptosis have been implicated in tumorigenesis, tumor progression, and immuno-therapy in cirrhotic hepatocellular carcinoma (HCC), indicating its association with extracellular matrix stiffness and immune checkpoint inhibitor. Here, we postulated that increased matrix stiffness reduces ferroptosis and impairs tumor immunity by regulating the expression of ferroptosis- and immune-related ge...

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Literature Corpus work
cfd8c290-3e6b-57e2-b503-d4937d66bbb2
DOI
10.21203/rs.3.rs-1389059/v1
Open publication

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Ferroptosis-related genes coordinated with PD-L2 shapes matrix stiffness-driven tumor environment and predict hepatocellular carcinoma developmentDOI 10.21203/rs.3.rs-1389059/v1
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