Article

Twin Analyses Without Zygosity Information: The Promise and Pitfalls of the Normal Finite-Mixture-Distribution Twin Model

2026-07-20

Abstract excerpt

<p>Twin designs offer a powerful framework for disentangling genetic and environmental sources of individual differences, but require zygosity information that is often unavailable. When zygosity is unknown, analyses may still be possible using a normal finite-mixture-distribution model. This model assumes that the bivariate twin phenotype is normally distributed within each zygosity group, an assumption that cann...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd8844f4-6856-5d8f-97fd-872e169b6b0e
DOI: 10.31234/osf.io/rkxgp_v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Twin Analyses Without Zygosity Information: The Promise and Pitfalls of the Normal Finite-Mixture-Distribution Twin ModelDOI 10.31234/osf.io/rkxgp_v3Read

Twin Analyses Without Zygosity Information: The Promise and Pitfalls of the Normal Finite-Mixture-Distribution Twin ModelSemantic proximity Read

Precision and bias of a normal finite mixture distribution model to analyze twin data when zygosity is unknown: simulations and application to IQ phenotypes on a large sample of twin pairs.Semantic proximity Read

A finite mixture model for genotype and environment interactions: detecting latent population heterogeneity.Semantic proximity Read

Advances in behavioral genetics modeling using Mplus: applications of factor mixture modeling to twin data.Semantic proximity Read

Applying Multivariate Discrete Distributions to Genetically Informative Count Data.Semantic proximity Read

A generalized Defries-Fulker regression framework for the analysis of twin data.Semantic proximity Read

Quantifying and addressing parameter indeterminacy in the classical twin design.Semantic proximity Read

Using non-normal SEM to resolve the ACDE model in the classical twin design.Semantic proximity Read

A statistical measure for the skewness of X chromosome inactivation for quantitative traits and its application to the MCTFR data.Semantic proximity Read

Why Accurate Knowledge of Zygosity is Important to Twins.Semantic proximity Read

Multivariate models of mixed assortment: phenotypic assortment and social homogamy for education and fluid ability.Semantic proximity Read

Evaluation of analyses of univariate discrete twin data.Semantic proximity Read