Article

Children and Adolescent Patients with Variants in the<i>ATP1A3</i>-encoded Sodium-Potassium ATPase Alpha-3 Subunit Demonstrate an Impaired QT Response to Bradycardia and Predisposition to Sinus Node Dysfunction

2024-09-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Alternating hemiplegia of childhood (AHC) is a rare disorder with both neurologic and cardiac manifestations. The ATP1A3-D801N variant is associated with a pathologically short QT interval and risk of ventricular arrhythmia following bradycardia; however, the mechanism of this remains unknown. We investigated the relationship between heart rate (HR), QT, and QTc, hypothesizing...

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Literature Corpus work: cbb48aae-60da-5025-ad2c-1d992f9d9b85
DOI: 10.1101/2024.08.31.24312446

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Children and Adolescent Patients with Variants in the<i>ATP1A3</i>-encoded Sodium-Potassium ATPase Alpha-3 Subunit Demonstrate an Impaired QT Response to Bradycardia and Predisposition to Sinus Node DysfunctionDOI 10.1101/2024.08.31.24312446Read

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