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Aggregation chimeras provide evidence of <i>in vivo</i> intercellular correction in ovine CLN6 neuronal ceroid lipofuscinosis (Batten disease)

2021-12-06

Abstract excerpt

The neuronal ceroid lipofuscinoses (NCLs; Batten disease) are fatal, mainly childhood, inherited neurodegenerative lysosomal storage diseases. Sheep affected with a CLN6 form display progressive regionally defined glial activation and subsequent neurodegeneration, indicating that neuroinflammation may be causative of pathogenesis. In this study, aggregation chimeras were generated from homozygous unaffected normal...

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Literature Corpus work
c9a04f32-86c0-5b77-91a3-e715c977bb1b
DOI
10.1101/2021.12.06.471461
Open publication

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Aggregation chimeras provide evidence of <i>in vivo</i> intercellular correction in ovine CLN6 neuronal ceroid lipofuscinosis (Batten disease)DOI 10.1101/2021.12.06.471461
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