Article

Esco2 and Cohesin Regulate CRL4 Ubiquitin Ligase <i>ddb1</i> Expression and Thalidomide Teratogenicity

2020-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Cornelia de Lange syndrome (CdLS) and Roberts syndrome (RBS) are severe developmental maladies that arise from mutation of cohesin (including SMC3, CdLS) and ESCO2 (RBS). Though ESCO2 activate cohesin, CdLS and RBS etiologies are currently considered non-synonymous and for which pharmacological treatments are unavailable. Here, we identify a unifying mechanism that integrates these genetic malad...

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Literature Corpus work: c94f296f-888f-5a7a-a765-214e86dc832f
DOI: 10.1101/2020.09.02.280149

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