Article

Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas based technology

2022-04-14

Abstract excerpt

<title>Abstract</title> <bold>Background</bold>Cornelia de Lange syndrome (CdLS) is a rare multisystem genetic disorder which is caused by genetic defects involving the Nipped-B-like protein (<italic>NIPBL</italic>) gene in the majority of clinical cases (60-70%). Currently, there are no specific cures available for CdLS and clinical management is needed for life. Disease models are highly needed to find a cur...

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Literature Corpus work: c7ae2f03-f566-542e-b48d-d0edaaf06c25
DOI: 10.21203/rs.3.rs-1529560/v1

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