Article

Role of short-chain fatty acids in the gut-brain axis in schizophrenia: contribution to immune activation and pathophysiology in humans and mice

2020-04-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Gut microbiota dysbiosis and aberrant gut-brain functional modules including short-chain fatty acid (SCFA) production and long-lasting immune activation (IA) are presented in schizophrenia. Given the key roles of gut microbiota and SCFA in shaping immunity, we propose that dysbiosis-induced SCFA upregulation could contribute to IA and behavioral symptoms in schizophrenia. <h4...

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Literature Corpus work: c77816c1-3c44-5784-b0a3-2c893b958ea0
DOI: 10.1101/2020.04.11.021915

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