Article

Newborn Screening for Methylmalonic Acidemia/propionic Acidemia: Systematic Evaluation of a Two-pronged Approach Based on MS/MS and UPLC-MS/MS

2021-08-13

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> An improved second-tier test is needed to reduce the false-positive rate of newborn screening (NBS) for inborn metabolic disorders in Xuzhou, China.<bold>Methods:</bold> We designed an expanded second-tier assay using newborn dried blood spots (DBSs). Analytical and clinical performance were evaluated in 53 newborns with methylmalonic acidemia (MMA) or propionic...

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Literature Corpus work: c5aacff3-7b2a-50c6-8904-ccb0bfd2a34c
DOI: 10.21203/rs.3.rs-801126/v1

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