Article
Proteasome Inhibitors Reduce Thrombospondin-1 Release in Human Dysferlin-Deficient Myotubes
2020-11-03
Abstract excerpt
<title>Abstract</title> <p><bold>Background</bold> Dysferlinopathies are a group of muscle disorders causing muscle weakness and absence or low levels of dysferlin, a type-II transmembrane protein and the causative gene of these dystrophies. Dysferlin is implicated in vesicle fusion, trafficking, and membrane repair. Muscle biopsy of patients with dysferlinopathy is characterized by the presence of inflammatory i...
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Identifiers and source
- Literature Corpus work
- c3df8809-fdb5-5c1d-9b3f-4fd773e4ad90
- DOI
- 10.21203/rs.2.19199/v3