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Multi-Omics Profiling Reveals Gene Signatures and Therapeutic Targets in HER2- Guided Gastric Cardia Adenocarcinoma Patients

2024-03-06

Abstract excerpt

Therapeutic targets for Gastric Cardia Adenocarcinoma (GCA), particularly for HER2- negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, and metabolomics. We found HER2 to be a favorable prognostic marker for GCA. Employing molecular counting, we categorized patients into HER2-high, -low, and -negative groups. We unco...

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Literature Corpus work
c3b7af4a-42f7-57c7-84cb-a2d1ab4929e6
DOI
10.1101/2024.03.02.583089
Open publication

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Multi-Omics Profiling Reveals Gene Signatures and Therapeutic Targets in HER2- Guided Gastric Cardia Adenocarcinoma PatientsDOI 10.1101/2024.03.02.583089
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