Article

Using Allen Brain Cell Atlas of the Human Brain to Gain Insights into the C-Terminal Binding Protein 1 (CTBP1)’s Potential Function

2025-03-09

Abstract excerpt

C-terminal binding proteins (CtBPs) dimerize and function predominantly as transcriptional corepressors by targeting various chromatin-modifying factors to promoter-bound repressors. Hypotonia, Ataxia, Developmental-Delay, and Tooth-Enamel Defects Syndrome (HADDTS) is a recently discovered neurodevelopmental disorder resulting from a heterozygous missense mutation in CTBP1. It is often associated with the early on...

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Literature Corpus work: c046371f-50c4-5ead-adfb-1c08875206ab
DOI: 10.20944/preprints202503.0508.v1

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