Article

Arboviral Coinfection and Clinical Severity in the Americas: An Integrative Review of Dengue, Chikungunya, and Zika Virus Interactions

2026-05-01

Abstract excerpt

<h4>Background: </h4> Dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) co-circulate across the Americas and share Aedes mosquito vectors, creating conditions for concurrent infections. Whether coinfection increases clinical severity remains uncertain because clinical syndromes overlap, diagnostic windows are short, and flavivirus serology is prone to cross-reactivity. <h4>Objective:</h4> To sy...

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Literature Corpus work: c027d4ab-e903-595d-be35-d97b34f3b6f7
DOI: 10.20944/preprints202604.2189.v1

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