Predictors of Response and Rational Combinations for the Novel MCL-1 Inhibitor MIK665 in Acute Myeloid Leukemia

Abstract excerpt

Despite promising anti-leukemic activity of MCL-1 inhibitors in preclinical studies of acute myeloid leukemia (AML), their progress through clinical evaluation has in part been challenged by limited knowledge of patient subgroups suitable for treatment. To stratify patients with AML for MCL-1 inhibitor-based treatment, we evaluated the sensitivity of 42 primary AML samples to MCL-1 inhibitor MIK665 (S64315) and co...

Topics

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• Acute Myeloid Leukemia Research
• Aged
• Antineoplastic Agents
• Chronic Lymphocytic Leukemia Research
• fms-Like Tyrosine Kinase 3
• Histone Deacetylase Inhibitors Research
• Leukemia, Myeloid, Acute
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

bfcf29f2-fa13-5fa3-af05-31bf9375e693

DOI

10.1101/2024.11.07.24316814