Article

Rest-Activity Rhythm Variability Across Clinical Episodes of Bipolar Disorder: Standalone Biomarker or Statistical Artifact?

2026-07-17

Abstract excerpt

<h4>Background</h4> Actigraphy-derived rest–activity rhythm (RAR) features are widely used to characterize clinical states in bipolar disorder (BD). Both mean levels and temporal variability of these features have been associated with mood episodes; however, variability measures are often statistically coupled with the mean, particularly in skewed distributions. This raises a question as to whether variability re...

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Literature Corpus work: befba862-60c9-5439-9c9f-1b9b6232142d
DOI: 10.64898/2026.07.15.26358139

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