Article

AI-aided design of novel targeted covalent inhibitors against SARS-CoV-2

2020-03-08

Abstract excerpt

The focused drug repurposing of known approved drugs (such as lopinavir/ritonavir) has been reported failed for curing SARS-CoV-2 infected patients. It is urgent to generate new chemical entities against this virus. As a key enzyme in the life-cycle of coronavirus, the 3C-like main protease (3CL pro or M pro ) is the most attractive for antiviral drug design. Based on a recently solved structure (PDB ID: 6LU7),...

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Literature Corpus work: ba54c26f-dd33-562c-b22f-bdb8c9ee6a80
DOI: 10.1101/2020.03.03.972133

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