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CRISPR-Cas9-Mediated Construction of a Streptococcus agalactiae Vaccine for Tilapia and Evaluation of Its Protective Efficacy

2026-04-09

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<title>Abstract</title> <p> <bold>Background</bold> Streptococcus agalactiae (GBS) causes severe tilapia streptococcosis with heavy aquaculture losses; existing vaccines have administration or efficacy limitations. This study used CRISPR-Cas9 to construct recombinant E. coli DH5α-ORF4-GFP (targeting GBS ScpB gene ORF4 fragment), optimized tilapia immersion immunization doses/frequencies, and evaluated the vacci...

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Literature Corpus work
ba4cd89e-7b68-5e2e-b15b-eac880139002
DOI
10.21203/rs.3.rs-9209433/v1
Open publication

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CRISPR-Cas9-Mediated Construction of a Streptococcus agalactiae Vaccine for Tilapia and Evaluation of Its Protective EfficacyDOI 10.21203/rs.3.rs-9209433/v1
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