Article

Novel treatment with sucrosomial magnesium for hypomagnesemia in Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis (FHHNC)

2025-04-16

Abstract excerpt

<title>Abstract</title> <p><bold>Introduction:</bold> Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis (FHHNC) is a rare autosomal recessive disorder caused by mutations in the CLDN16 and CLDN19 genes, which encode claudins essential for paracellular magnesium and calcium reabsorption in the thick ascending limb. This defect results in significant renal magnesium loss, hypercalciuria, and progress...

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Literature Corpus work: b6931c27-aaf0-5df8-ab9d-27454cb49dca
DOI: 10.21203/rs.3.rs-6302820/v1

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