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T-Cell Exhaustion-Related Gene Signatures Predict Clinical Outcomes and Immunotherapy Response in Kidney Renal Clear Cell Carcinoma

2024-09-08

Abstract excerpt

<title>Abstract</title> <p>T-cell exhaustion (TEX) is a crucial immune escape mechanism and a pathway of resistance in cellular immunotherapy, yet its prognostic role in kidney renal clear cell carcinoma (KIRC) remains unclear. This study analyzed 518 KIRC patients from the TCGA dataset, identifying TEX-related genes through Gene Set Variation Analysis (GSVA) and Weighted Gene Co-Expression Network Analysis (WGCN...

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Literature Corpus work
b5964927-03a9-5ac1-b36d-86309d35c616
DOI
10.21203/rs.3.rs-4802145/v1
Open publication

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