Article

Evaluating the Use of GLP-1 Receptor Agonists in Wolfram syndrome Patients

2026-04-02

Abstract excerpt

Wolfram syndrome is a rare autosomal recessive disorder caused by pathogenic variants in the WFS1 gene, characterized by early-onset diabetes mellitus, optic atrophy, sensorineural hearing loss, arginine vasopressin deficiency, and progressive neurodegeneration. The condition selectively affects pancreatic β cells and neurons via chronic endoplasmic reticulum (ER) stress, and no proven disease-modifying therapy c...

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Literature Corpus work: b551a036-1fa0-56bc-b1e7-eadfc632d013
DOI: 10.64898/2026.03.31.26349885

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