Article

Clinical trajectories and genetic architecture across the neurological–psychiatric boundary

2026-08-10

Abstract excerpt

Foundation models trained on health records are increasingly used to represent human disease, but whether their embeddings reflect biology is hard to establish. We validate disease trajectory embeddings from an attention-based transformer against an external signal: genome-wide genetic architecture. Across 19 neurological and psychiatric disorders, clinical trajectory similarity mirrors genetic similarity, and the...

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Literature Corpus work: b155e7b0-8f77-5240-bcdb-08a3684786d8
DOI: 10.64898/2026.08.06.26359855

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