Article

Mitochondrial ncRNA LDL-805 declines in alveolar epithelial type 2 cells of chronic obstructive pulmonary disease patients

2024-01-15

Abstract excerpt

<h4>Rationale</h4> We showed that levels of a murine mitochondrial noncoding RNA, mito-ncR-LDL805 , increase in alveolar epithelial type 2 cells exposed to extracts from cigarette smoke. The transcripts translocate to the nucleus, upregulating nucleus-encoded mitochondrial genes and mitochondrial bioenergetics. This response is lost after chronic exposure to smoke in a mouse model of chronic obstructive pulmonar...

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Literature Corpus work: af787c0d-287e-5412-8f0a-c97058a44389
DOI: 10.1101/2024.01.14.575591

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