Back to search

Article

APLN, a novel prognostic biomarker, contributes to esophageal carcinoma development

2025-09-25

Abstract excerpt

<title>Abstract</title> <p>Background: Esophageal carcinoma (ESCA) is a highly aggressive malignancy with poor prognosis. The apelin gene (APLN) encodes a secreted peptide involved in various physiological processes, but its role in ESCA progression and chemoresistance remains unclear. <h4>Methods:</h4> We integrated transcriptomic data from TCGA and GEO databases with CRISPR screening to identify key oncogenes i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ae5e8d1c-6507-5406-a17b-88558a69cc5f
DOI
10.21203/rs.3.rs-7592740/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
APLN, a novel prognostic biomarker, contributes to esophageal carcinoma developmentDOI 10.21203/rs.3.rs-7592740/v1
Elucidating the Correlation between Leupaxin as a Prognostic Biomarker and Immunotherapeutic Efficacy in Esophageal Squamous Cell CarcinomaSemantic proximity
Identification of pyroptosis-related lncRNAs as potential prognostic biomarkers in patients with adenocarcinoma of the esophagogastric junctionSemantic proximity
Leupaxin: A Prospective Therapeutic Target for Esophageal Squamous Carcinoma TreatmentSemantic proximity
Identification and validation of an anoikis-related gene signature based on machine learning algorithms in esophageal squamous cell carcinomaSemantic proximity
Expression of ASPN with Prognostic Values in Gastric Cancer: A Study Based on TCGA DataSemantic proximity
A Novel Autophagy-Related Long Non-Coding RNA Signature to Predict Prognosis and Therapeutic Response in Esophageal Squamous Cell CarcinomaSemantic proximity
Multi-omics Profiling and Experimental Validation Identify APLNR as a Prognostic Biomarker Involved in Epithelial-Mesenchymal Transition and Immune Modulation in Gastric CancerSemantic proximity
H3K4me3 and H3K27ac Activated lncRPL34-AS1 Acts as a Suppressor of Esophageal Squamous Cell Carcinoma via Targeting miR-575/ACAA2 Axis and Binding to ALOX12B and CATSemantic proximity
Development and validation of an autophagy-related prognostic signature in esophageal cancerSemantic proximity
Construction of a peptidase gene-based prognostic prediction model for esophageal carcinoma and identification of IMMP1L as a potential tumor biomarkerSemantic proximity
Profiles of autophagy-related genes in esophageal adenocarcinomaSemantic proximity
Bioinformatics analysis and experimental verification of NLRX1 as a prognostic factor for esophageal squamous cell carcinomaSemantic proximity
Select a neighboring publication to make it the new centre.