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The Unrestricted Global effort to complete the Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (COOL) Trial

2023-02-24

Abstract excerpt

· <h4>Background: </h4> Severe complicated intra-abdominal sepsis (SCIAS) has an increasing incidence with mortality rates over 80% in some settings. Mortality typically results from disruption of the gastrointestinal tract, progressive and self-perpetuating bio-mediator generation, systemic inflammation, and multiple organ failure. A further therapeutic option may be open abdomen (OA) management with negative per...

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Literature Corpus work
ab8940c0-3607-5c8a-857b-977306797962
DOI
10.21203/rs.3.rs-2613812/v1
Open publication

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