Article
KaryoScope: rapid, alignment-free sequence annotation for the pangenome era
2026-05-17
Abstract excerpt
The pangenome era is producing long-read sequencing data and complete genome assemblies (1–3) at a pace that current annotation methods cannot match. Existing tools were each built for a single feature class (repeats, centromeric satellites, or genes) and falter precisely where the genome is most variable and harbours clinically important variation: the centromeres, subtelomeres, and acrocentric short arms. Here w...
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Identifiers and source
- Literature Corpus work
- a55aa23d-5cac-5511-88d7-a99ff6b080d4
- DOI
- 10.64898/2026.05.15.725544