Article

Binding affinity improvement analysis of multiple-mutant Omicron on 2019-nCov to human ACE2 by In-silico predictions

2022-03-24

Abstract excerpt

<title>Abstract</title> <p>Since the outbreak of COVID-19 in 2019, the 2019-nCov coronavirus has appeared diverse mutational characteristics due to its own flexible conformation. One multiple-mutant strain (Omicron) with surprisingly infective activity outburst, and affected the biological activities of current drugs and vaccines, making the epidemic significantly difficult to prevent and control, and seriously t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3e1ef54-1c44-5ea8-b7a8-1d7949aa013b
DOI: 10.21203/rs.3.rs-1453181/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Binding affinity improvement analysis of multiple-mutant Omicron on 2019-nCov to human ACE2 by In-silico predictionsDOI 10.21203/rs.3.rs-1453181/v1Read

Binding affinity improvement analysis of multiple-mutant Omicron on 2019-nCov to human ACE2 by in silico predictions.Semantic proximity Read

In Silico Prediction of New Mutations That Can Improve the Binding Abilities Between 2019-nCoV Coronavirus and Human ACE2.Semantic proximity Read

Critical Sequence Hot-spots for Binding of nCOV-2019 to ACE2 as Evaluated by Molecular SimulationsSemantic proximity Read

Enhancement of SARS-CoV-2 Receptor Binding Domain -CR3022 Human Antibody Binding Affinity via in Silico Engineering ApproachSemantic proximity Read

Critical Sequence Hotspots for Binding of Novel Coronavirus to Angiotensin Converter Enzyme as Evaluated by Molecular SimulationsSemantic proximity Read

Predictions for the binding domain and potential new drug targets of 2019-nCoVSemantic proximity Read

Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionSemantic proximity Read