Oxymatrine mediated prevention of amyloid β-peptide induced apoptosis on Alzheimer's model PC12 cells an in vitro cell culture studies and in vivo cognitive assessment in rats

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is a major neurological disease affecting elder people worldwide. Existing drugs only reduce the symptoms of the disease. Commonly, Aβ25–35 peptide aggregation is the main reason for AD development. Recently, the discovery of multiple protein-targeting molecules is a new strategy for AD treatment. This study demonstrates the neuroprotective potential of oxymatri...

Topics

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• Alzheimer Disease
• Amyloid beta-Protein Precursor
• Apolipoprotein E4
• Apolipoproteins E
• Cholinesterase Inhibitors
• Neuroprotective Agents
• Presenilin-1
• Presenilin-2

Identifiers and source

Literature Corpus work

a2894015-1e8b-5a10-9fcd-ab1675b9a791

DOI

10.21203/rs.3.rs-2616242/v1