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Interferon-Induced Monocyte Immune Response Augments Immunotherapy and Correlates with Clinical Outcomes in Breast Cancer

2023-10-17

Abstract excerpt

In this study, we established comprehensive single-cell transcriptomic profiles of myeloid cells and T cells in breast cancer and identified a group of monocytes that secrete various chemokines to promote anti-tumor immunity and respond to interferon-gamma (IFN-γ), as well as a group of T cells that self-secrete IFN-γ. Notably, these T cells not only serve as targets of IFN-γ but can also produce IFN-γ themselves....

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Literature Corpus work
a231d3d6-b0d6-54d4-997a-bc4da946c2c8
DOI
10.21203/rs.3.rs-3436350/v1
Open publication

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